TIMI FLOW CLASSIFICATION ACTIVATOR
Sixty minute alteplase protocol: a new accelerated recombinant tissue type plasminogen activator regimen for thrombolysis in acute myocardial infarction. Gulba DC, Tanswell P, Dechend R, Sosada M, Weis A, Waigand J, et al. Frequent lack of concordance among core laboratories in assessing TIMI flow grade after reperfusion therapy. The TIMI Frame Count: a quantitative method of assessing coronary artery flow. Gibson CM, Cannon CP, Daley WL, Dodge JT, Alexander B, Marble SJ, et al. The Thrombolysis in Myocardial Infarction (TIMI) trial. This process is experimental and the keywords may be updated as the learning algorithm improves. These keywords were added by machine and not by the authors.
The goal of this chapter is to review these two methods and to discuss the insights into the pathophysiology of acute coronary syndromes provided by these indexes of coronary blood flow.
In contrast to the TIMI flow grades, which are subjective categoric variables, the TIMI frame count is an objective continuous variable (2). To overcome them, the TIMI Angiographic Core Laboratory developed a new index of coronary blood flow called the TIMI Frame Count (2). Although this scheme has been a valuable tool for comparing the efficacy of reperfusion strategies and identifying patients at higher risk of adverse outcomes in acute coronary syndromes, it has limitations (2,3). For over a decade now, the Thrombolysis in Myocardial Infarction (TIMI) flow grade classification scheme has been successfully used to assess coronary blood flow in acute coronary syndromes (1).
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